Osteogenic Action of Parathyroid Hormone-Related Peptide (1-141) in Rat ROS Cells.
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چکیده
منابع مشابه
Interaction of human parathyroid hormone-related peptide with parathyroid hormone receptors in clonal rat osteosarcoma cells.
Synthetic peptides corresponding to the amino-terminal region of the human parathyroid hormone-related peptide (hPTHrp) were used to characterize the interaction of hPTHrp with parathyroid hormone (PTH) receptors in clonal rat osteosarcoma cells (ROS 17/2.8). Both hPTHrp-(1-34) and [Tyr40]hPTHrp-(1-40) showed full agonist activity in stimulating cyclic AMP accumulation in ROS cells; human PTHrp...
متن کاملThe Bipartite Action of Parathyroid Hormone-related Peptide on Cartilage
軟骨の研究は,骨 代謝研究のなかでも発生生物学的な アプロー チの視点から急速に進歩 してきた領域の1つ で ある。軟骨細胞の分化増殖,さ らに軟骨内骨化に対する 調節因子の研究は,基 礎的な細胞生物学ばか りでなく先 天異常を含めた遺伝子疾患の解明にも及び,そ の必要性 が再認識 されている(図1)。 そのなかで副甲状腺ホルモ ン関連ペ プチ ド(parathyroid hormone-related peptide: PTHrP)は,軟 骨の分化増殖に最 も重要な因子で あり,多 くの研究者によってその詳細が明 らかにされて いる。PTHrPに ついては,す でに1950年 代 にAlbright が,悪 性腫瘍から産生される副甲状腺ホルモン(PTH) 様の物質でありhumoral hypercalcemia of malignancy の高カルシウム血症の起因物質 としてその存...
متن کاملParathyroid hormone-related peptide expression in rat collagen-induced arthritis.
OBJECTIVES The aim of this study was to describe expression of parathyroid hormone-related peptide (PTHrP) in collagen-induced arthritis (CIA), a well-established animal model for rheumatoid arthritis. METHODS CIA was induced in female dark agouti rats. Inguinal (ILNs) and popliteal (PLNs) lymph nodes and distal interphalangeal joints (DIP) were retrieved at different time points. Tissues wer...
متن کاملExpression of parathyroid hormone-related protein and the parathyroid hormone/parathyroid hormone-related protein receptor in rat thymic epithelial cells.
Thymic epithelial cells are an important source of cytokines and other regulatory peptides which guide thymocyte proliferation and maturation. Parathyroid hormone-related protein (PTHrP), a cytokine-like peptide, has been reported to affect the proliferation of lymphocytes in vitro. The studies presented here were undertaken to test the hypotheses that PTHrP is produced locally within the thymu...
متن کاملParathyroid Hormone-Related Peptide and Vitamin D in Phosphocalcic Metabolism for Dromedary Camel
In mammals, phosphocalcic and bone metabolisms are mainly regulated by parathyroid hormone, parathyroid hormone-related peptide (PTHrP) and 1α,25-dihydroxyvitamin D or calcitriol. In camels, circulating levels of calcitriol are 10 times higher than those determined in other ruminants and further increase during early lactation. Calcitriol and parathyroid-related peptide stimulate intestinal abs...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 1996
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.43.527